Thursday, November 27, 2008

Building Stronger Bones

Building Stronger Bones
By Jean Lawrence

One in two women and one in four men over age 50 will have an osteoporosis-related fracture in her/his remaining lifetime. Yes, osteoporosis ("porous bones") affects men, too. Yet the advanced effects of bone loss -- a humped upper back or easily shattered limbs -- does not have to be in the future of people who eat wisely and exercise regularly.

Bones are living tissue. They contain nerves, blood vessels, and marrow, where blood cells are created. Bones are constantly tearing down and rebuilding themselves, like a freeway construction project that never ends. Without this repair and reinforcement of even minor weak spots, we would break bones on a regular basis.

"When a person us under 20 years of age," explains Felicia Cosman, MD, medical director of the Clinical Research Center at Helen Hayes Hospital in New York and clinical director of the National Osteoporosis Foundation, "you are forming more bone cells than you are losing." But when women near menopause, rebuilding new bone slows down. A woman's bone density begins to decrease.

Bone density is measured by a painless, low-radiation X-ray, which is translated into what Cosman describes as a "sort of confusing number" called a T-score. Basically, the patient's bone density is compared to that of an average person between 20 and 30 years old -- the time of peak bone density in a woman's life. The lower the score the greater the risk of having a fracture.

A T-score of minus two or below should concern a 55-year-old woman, Cosman says; it indicates osteoporosis and might justify medication. A normal score is between +1 and -1.
Steps You Can Take to Prevent Osteoporosis

To prevent porous, breakable bones as you age, you need to have sufficient calcium and vitamin D. The body uses calcium for a number of functions and will take it out of the bones faster than it can be laid down if your diet does not pump enough calcium into the pipeline. But calcium is not the only component -- bones are also one-third collagen, which is a protein that gives bones their flexibility.

Annemarie Colbin, PhD, author of Food and Our Bones: The Natural Way to Prevent Osteoporosis, urges us to look at the animals with the largest bones -- cows, elephants. "What do they eat?" she asks. "Leafy plants."

The biggest component of a bone-healthy diet is leafy greens, both cooked and raw, according to Colbin. "Greens give you not only calcium, but vitamin K, potassium, and other minerals and nutrients you need to lay down bone. My first three recommendations are vegetables, vegetables, vegetables," she says with a laugh.

Vitamin D is also important for strong bones, and a good source is, believe it or not, the sun. Colbin recommends being out 20 minutes a day with no sunblock (SPF 8 or above blocks vitamin D), but Cosman vehemently disputes the wisdom of ever going out without sunblock and recommends a multivitamin or vitamin D supplement.
Steps You Can Take to Prevent Osteoporosis continued...

Another building block of strong bones is protein (remember that collagen?). Colbin says mix it up -- beans, fish, chicken. "You can't eat the same boring diet every day." Again, she urges you to select good-quality, properly raised, antibiotic-free protein sources. She also recommends making your own stock from animal bones -- add a tablespoon of vinegar to 8 cups of water to pull the calcium out of the bones. Throw in a carrots, onions, pepper -- and all you need is some garlic bread! If that isn't enough richness, Colbin recommends adding kombu or canten, mineral-loaded, flavorless seaweeds found in health food stores.

Whole grain bread or pasta is helpful, too. "This gives you magnesium," Colbin says. "You need sufficient magnesium to absorb the calcium you are putting in.
What About Milk or Supplements?

It's almost a mantra -- drink milk for strong bones. Colbin is low-key on milk. "You see the most fractures in countries that drink a lot of milk," she says. "I am not too keen on dairy."

Cosman is also not enthused. "A lot of people drink milk, but I am not big on that," she says. "Maybe low-fat milk or yogurt. Those calcium-enriched juices are good."

Not so good are sugar (increasing secretion of calcium and trace elements), caffeine (ditto), stress, and habitual dieting, which can "starve" your bones.

So what does that leave? Besides veggies and fruits, most women, at least the ones over 50, probably need some calcium supplements in the form of pills.

People over the age of 50 need about 1,200 mg a day, according to the American Medical Association.

She also recommends everyone take a multivitamin (and the American Medical Association agrees). Should you take calcium citrate or calcium carbonate? Despite the raging debate on this, Cosman says the data are not conclusive. Consult your healthcare provider for a decision. There are some rare medical conditions that make calcium citrate preferable.

Incidentally, if you do take a calcium pill, take it at a time of day when you did not just eat a lot of calcium. If you have milk and fortified juice at breakfast, Cosman recommends taking the calcium pill at lunch.
Exercise

Bones last longer if you stress them more. It's one of those medical conundrums. Exercising -- putting the weight of your body or an outside weight on the bone -- makes it lay down more bone material to strengthen it. "Use it or lose it!" quips Colbin. "Any exercise is better than none."

Cosman agrees. "Ideally, several times a week -- and you need aerobic, weight bearing, and resistance."

But be careful -- heavy weights or too vigorous exercise in women with osteoporosis might trigger a fracture.

Colbin even recommends against big, fat running shoes. "You don't want that cushioning for this," she says. (Older people also tend to fall and break bones less when they don't wear what amounts to a platform shoe.) Basically, she says, walk a lot and carry stuff.

It works. A study done the University of Toronto shows that aerobic exercise, such as walking, jogging, or dance, improved the amount of calcium in the upper body and upper thighs, two areas at risk for fractures.
Medications for Bone Loss

If you have suffered bone loss, a number of medications exist to slow the resorption cycle so more bone remains. A new medication called Forteo is the first to build bone. "It's very potent," says Cosman, "and is only for those diagnosed with osteoporosis, not for prevention." For one thing, Forteo is given by a daily injection.

Another medication popularly prescribed is Fosamax. This has been shown to reduce the risk of fractures but is a little tricky to take (you have to sit up afterward to prevent burning of the esophagus).

What about good old estrogen replacement? Hormone replacement therapy is approved for prevention and treatment of osteoporosis, but a much publicized study was stopped because one form of it increased the risk of breast cancer and other maladies. Cosman recommends against taking estrogen just for bone health.

Instead of a shelf full of pills, most people only need a well-stocked refrigerator. The process of bone remodeling is complicated but is hooked into the nutrients available to maintain your bones.

"You can't put every little molecule in cauliflower into a pill," Cosman says. "It's simpler to eat the cauliflower." Words to live by.

Star Lawrence is a medical journalist based in the Phoenix area.

SOURCES: Felicia Cosman, MD, medical director, Clinical Research Center, Helen Hayes Hospital, New York; and clinical director, National Osteoporosis Foundation. Annemarie Colbin, PhD, author, Food and Our Bones: The Natural Way to Prevent Osteoporosis. National Osteoporosis Foundation web site

Thanksgiving Turkey -- More Than Just Delicious


Thanksgiving Turkey -- More Than Just Delicious

By Jackie Silver


LegThanksgiving is right around the corner, so let's talk turkey. Most people already know that turkey is an excellent source of protein, but did you also know that turkey is a good source of cancer-preventive selenium?1 Selenium is an essential component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defense systems and immune function.

Selenium has been shown to induce DNA repair2 and synthesis in damaged cells, inhibit the growth of cancer cells and rev up the self-destruct sequence the body uses to eliminate worn out or abnormal cells. But that's not all...

Vitamin B6 is an important vitamin present in turkey, as well as niacin, which plays a role in maintaining good cholesterol.3 B6 is needed for more than 100 enzymes involved in protein metabolism, according to the National Institutes of Health.4 It's also essential for red blood cell metabolism and for the proper function of your nervous and immune systems. So, even if your eyes glazed over from all that scientific mumbo jumbo, you can rest assured that your body and your taste buds will enjoy your Thanksgiving turkey!

Have you ever cooked your turkey to the USDA-recommended5 165 degrees and found that it's still pink next to the bone? It may simply be a very young turkey. Its immature bones may allow hemoglobin to leach into the meat, but it's still safe to eat.6 Here's another quick tip: don't cook your turkey with the dressing stuffed inside -- you may be risking a case of food poisoning.7 Instead, try this original recipe, cooked separately, as an Aging Backwards side dish.

Original Thanksgiving Recipe: Aging Backwards Stuffing with Cranberry

1 package store-bought, flavored stuffing
2 stalks celery, chopped
1 onion, chopped
3 tablespoons of Brazil nuts, chopped (good source of selenium)
1/4 cup dried cranberries
1 cup hot water

Pour hot water over dried cranberries and set aside. Sauté celery and onion until soft. Prepare stuffing mix per package directions and add sautéed celery, onions, chopped Brazil nuts and plumped cranberries. Spoon mixture into casserole dish and bake at 350 degrees for 15 minutes. Serve a small portion as a side to turkey. Remember, portion control is conducive to Aging Backwards.

Here's why cranberry stuffing is a great choice for your Thanksgiving turkey. The medical and health community recognizes antioxidants as premier disease fighters, and cranberries have been shown to contain more antioxidants than 19 commonly eaten fruits. According to a recent study, these antioxidants may play a role in helping to prevent certain cancers and heart disease.8

References

1. http://www.cancerproject.org/protective_foods/selenium.php
2. http://jnci.oxfordjournals.org/cgi/content/full/95/2/98
3. http://www.sciencedaily.com/releases/2008/06/080605150904.htm
4. http://ods.od.nih.gov/factsheets/vitaminb6.asp
5. http://www.fsis.usda.gov/Fact_Sheets/
6. http://www.urbanext.uiuc.edu/Turkey/faqs.html
7. http://news.bbc.co.uk/2/hi/health/1715751.stm
8. http://www.cranberryinstitute.org/news/PR/PR062001.htm

10 Early Warning Signs of Alzheimer's Disease


10 Early Warning Signs of Alzheimer's Disease

By Layne Lowery


Early symptoms of Alzheimer's disease differ by individual, as well as day-to-day. Some signs may be so subtle that they may go unnoticed by family or friends, while other symptoms will become increasingly obvious over time.

The following checklist was written by the Alzheimer's Association1 to assist individuals determine if they or a loved one have the early warning signs of the disease. We thank them for making this valuable information available to the public.

1. Memory loss. One of the most common early signs of dementia is forgetting recently learned information. While it's normal to forget appointments, names or telephone numbers, those with Alzheimer's disease will forget such things more often and not remember them later.

2. Difficulty performing familiar tasks. People with Alzheimer's disease often find it hard to complete familiar, everyday tasks which they previously did without thinking. A person with Alzheimer's may forget how to cook, make repairs or how to play cards.

3. Problems with language. Everyone has trouble finding the right word occasionally, but a person with Alzheimer's disease often forgets simple words or substitutes unusual words.

4. Disorientation to time and place. It's normal to forget the day of the week or where you are going. But people with Alzheimer's disease can become lost on their own street, forget where they are and how they got there, and not know how to get back home.

5. Poor or decreased judgment. No one has perfect judgment all of the time. Those with Alzheimer's may dress without regard to weather, wearing several shirts or blouses on a warm day, or very little clothing on a cold day. Individuals with Alzheimer's disease often show poor judgment about money, giving away large amounts of money to telemarketers, overpaying for home repairs or buying products they don't need.

6. Problems with abstract thinking. Balancing a checkbook may be hard when the task is more complicated than usual. Someone with Alzheimer's disease could forget completely what the numbers are and what needs to be done with them.

7. Misplacing things. Anyone can temporarily misplace a wallet or key. A person with Alzheimer's may put things in unusual places: An iron in the freezer or a wristwatch in the sugar bowl.

8. Changes in mood or behavior. Everyone can become sad or moody. Someone with Alzheimer's disease can show rapid mood swings (from calm to tears to anger) for no apparent reason.

9. Changes in personality. People's personalities ordinarily change somewhat with age. But a person with Alzheimer's disease can change a lot, becoming extremely confused, suspicious, fearful or dependent on a family member.

10. Loss of initiative. It's normal to tire of housework, business activities or social obligations at times. The person with Alzheimer's may become very passive, sitting in front of the television for hours, sleeping more than usual, or not wanting to do usual activities.

Can Alzheimer's Disease be Prevented?

So far there is no guaranteed way of preventing Alzheimer's disease. But ongoing research is revealing some exciting possibilities for warding off the disease:

Exercising the Brain. People who keep their brains active by reading or doing jigsaw puzzles, word games or chess are less likely to have Alzheimer's disease. "We found that frequency of cognitive activity, but not of physical activity, was associated with risk of developing Alzheimer's disease and the rate of cognitive decline. We found that compared to persons with infrequent cognitive activity, risk of developing Alzheimer's disease was reduced by about 50% in people who were frequently cognitively active," said Robert Wilson, Ph.D.1

"There has been an emerging concept from a number of studies that brain reserve may be a protective factor against Alzheimer's disease... there's a suggestion that people with lower levels of formal education have a higher risk of Alzheimer's disease. And so that would be an early-to-adult life influence on the brain reserve. What [studies] may show is that perhaps staying active during later life could modulate or sustain brain function, and again, that could possibly be protective," said Douglas Galasko, M.D., professor of the department of neurosciences at the University of California-San Diego and staff scientist at the VA San Diego Healthcare System.

Exercising your body. Thirty minutes of daily activity has tremendous benefit to the heart, muscles and brain. Walk, garden, clean your house, rake leaves, go dancing or exercise (try minimal exercises while still sitting in your chair).

Drinking plenty of fluids. Dehydration (not having enough water, juices, milk or other fluids) is a major factor in temporary memory loss. Drink plenty of fluids and cut down or eliminate alcohol.

Use caution with medications. Your doctor should know all the over-the-counter and prescribed medications you are taking. Some combinations may cause confusion or forgetfulness, and even long-term damage to your memory.

Eat a healthy diet. Eat five fruits and vegetables a day to promote a healthy mind and body. Dark greens and leafy vegetables, like broccoli, spinach and romaine lettuce, are especially beneficial.

Supplement the brain with Phosphatidylserine (PS).2 Several double-blind clinical studies suggest that taking phosphatidylserine during the early stages of Alzheimer's disease can slow the rate of deterioration for those suffering from Alzheimer's. So, the earlier a person begins taking phosphatidylserine, the better--especially when the disease runs in the family.

Here are some examples of promising research:

* Forty patients with probable Alzheimer's disease received either social support, cognitive training only or cognitive training in combination with pyritinol (a derivative of vitamin B6) or phosphatidylserine. After six months, patients given cognitive training plus phosphatidylserine showed "a significant glucose enhancement during the stimulation tasks in various brain regions and improvement in cognitive functioning compared to the other groups."

* Fifty-one patients meeting clinical criteria for probable Alzheimer's disease were studied. Patients were treated for 12 weeks with a formulation of phosphatidylserine or placebos. Patients treated with the phosphatidylserine drug improved on several cognitive measures compared with those who were given placebos. Differences between treatment groups were most apparent among patients with less severe cognitive impairment. Results suggest that phosphatidylserine may be a promising candidate for study in the early stages of Alzheimer's disease.

Remember, early diagnosis of Alzheimer's disease or other disorders causing dementia is an important step in getting appropriate treatment, care and support services, and maintaining the quality of life for a longer period of time.

Resources

Resources Alzheimer's Association, 919 North Michigan Avenue, Suite 1000, Chicago, IL 60611-1676; 1-800-272-3900. This is the largest national voluntary health organization supporting Alzheimer's research and care. They can help find a local Alzheimer's chapter that often has video lending libraries, caregiver support and more.

Alzheimer's Disease Education & Referral Center (ADEAR), Service of the National Institute on Aging, P.O. Box 8250, Silver Spring, MD 209078250. The U.S. Congress created ADEAR in 1990 to compile, archive and disseminate information on Alzheimer's disease to the public. ADEAR is operated as a service of the National Institute on Aging and National Institutes of Health. Call 1-800-438-4380.

References

1. Alzheimer's Association, 919 North Michigan Avenue, Suite 1000, Chicago, IL 60611- 1676; 1-800-272-3900.
2. Wilson, RS et al. Neurology, Nov 2007; 69: 1911-1920.
3. Balch, J. Prescription for Healthy Living (newsletter).